Human blood IgM " memory " B cells are circulating splenic marginal zone B cells
نویسندگان
چکیده
The human peripheral B cell compartment displays a large population of IgM IgD CD27 memory B cell carrying a mutated Ig + + + “ ” receptor. We show here, by phenotypic analysis, CDR3 spectratyping during a T-independent response and gene expression profiling of the different blood and splenic B cell subsets, that blood IgM IgD CD27 cells correspond to circulating splenic marginal zone B cells. + + + Furthermore, analysis of this peripheral subset in normal children below 2 years shows that these B cells develop and mutate their Ig receptor during ontogeny, prior to their differentiation into T-independent antigen-responsive cells. It is therefore proposed that these IgM IgD CD27 B cells provide the splenic marginal zone with a diversified and protective pre-immune repertoire in charge of the + + + responses against encapsulated bacteria. MESH
منابع مشابه
Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire.
The human peripheral B-cell compartment displays a large population of immunoglobulin M-positive, immunoglobulin D-positive CD27(+) (IgM(+)IgD(+)CD27(+)) "memory" B cells carrying a mutated immunoglobulin receptor. By means of phenotypic analysis, complementarity-determining region 3 (CDR3) spectratyping during a T-independent response, and gene-expression profiling of the different blood and s...
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The human peripheral B cell compartment displays a large population of IgMIgDCD27 “memory” B cell carrying a mutated Ig receptor. We show here, by phenotypic analysis, CDR3 spectratyping during a T-independent response and gene expression profiling of the different blood and splenic B cell subsets, that blood IgMIgDCD27 cells correspond to circulating splenic marginal zone B cells. Furthermore,...
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